Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC

Chaib, I.; Karachaliou, Niki; Pilotto, S.; Codony Servat, Jordi; Cai, Xueting; Li, Xuefei; Drozdowskyj, A.; C. Servat, C.; Yang, Jie; Hu, Chunping; Cardona, A.; L. Vivanco, G.; Vergnenegre, A.; Sánchez, J.; Provencio, M.; Reguart, N.; Zhou, Caicun; Cao, Peng; C. Ma, Patrick; Bivona, T.; Rosell, Rafael; Chaib, I.; Karachaliou, Niki; Pilotto, S.; C. Servat, J.; Cai, Xueting; Li, Xuefei; Drozdowskyj, A.; C. Servat, C.; Yang, Jie; Hu, Chunping; Cardona, A.; L. Vivanco, G.; Vergnenegre, A.; Sánchez, J.; Provencio, M.; de Marinis, F.; Passaro, A.; Carcereny, E.; Reguart, N.; Garcia Campelo, Charo; Teixidó, C.; Sperduti, I.; Rodríguez, S.; Lazzari, C.; Verlicchi, A.; de Aguirre, I.; Queralt, C.; Wei, Jia; Estrada, R.; P. de la Bellacasa, R.; Ramírez, J.; Jacobsen, Kirstine; Ditzel, H.; Santarpia, M.; Viteri, S.; Molina, M.; Zhou, Caicun; Cao, Peng; C. Ma, Patrick; Bivona, T.; Rosell, Rafael

doi:10.1093/jnci/djx014

Public

Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC

Shared by NobleBlocks on Mar 31, 2017 • 12:00 AM UTC

Authors:

I. Chaib

Niki Karachaliou

S. Pilotto

Abstract

Background: The efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in EGFR-mutant non–small cell lung cancer (NSCLC) is limited by adaptive activation of cell survival signals. We hypothesized that both signal transducer and activator of transcription 3 (STAT3) and...

Subject

Biology

Medicine

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!