Lipophilic salts of poorly soluble compounds to enable high-dose lipidic SEDDS formulations in drug discovery.

M, Morgen; A, Saxena; XQ, Chen; W, Miller; R, Nkansah; A, Goodwin; J, Cape; R, Haskell; C, Su; O, Gudmundsson; M, Hageman; A, Kumar; GS, Chowan; A, Rao; VK, Holenarsipur

doi:10.1016/j.ejpb.2017.04.021

Public

Lipophilic salts of poorly soluble compounds to enable high-dose lipidic SEDDS formulations in drug discovery.

Shared by NobleBlocks on Apr 21, 2017 • 12:00 AM UTC

Authors:

Morgen M

Saxena A

Chen XQ

Abstract

Self-emulsifying drug delivery systems (SEDDS) have been used to solubilize poorly water-soluble drugs to improve exposure in high-dose pharmacokinetic (PK) and toxicokinetic (TK) studies. However, the absorbable dose is often limited by drug solubility in the lipidic SEDDS vehicle. This study focus...

Subject

Emulsion

Atazanavir

2-Naphthalene Sulfonic Acid

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