Aspirin Use and Colorectal Cancer Survival According to Tumor CD274 (Programmed Cell Death 1 Ligand 1) Expression Status.

T, Hamada; Y, Cao; ZR, Qian; Y, Masugi; JA, Nowak; J, Yang; M, Song; K, Mima; K, Kosumi; L, Liu; Y, Shi; Silva A, da; M, Gu; W, Li; N, Keum; X, Zhang; K, Wu; JA, Meyerhardt; EL, Giovannucci; M, Giannakis; SJ, Rodig; GJ, Freeman; D, Nevo; M, Wang; AT, Chan; CS, Fuchs; R, Nishihara; S, Ogino

doi:10.1200/jco.2016.70.7547

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Aspirin Use and Colorectal Cancer Survival According to Tumor CD274 (Programmed Cell Death 1 Ligand 1) Expression Status.

Shared by NobleBlocks on Apr 13, 2017 • 12:00 AM UTC

Authors:

Hamada T

Cao Y

Qian ZR

Abstract

Purpose Blockade of the programmed cell death 1 (PDCD1, PD-1) immune checkpoint pathway can improve clinical outcomes in various malignancies. Evidence suggests that aspirin (a widely used nonsteroidal anti-inflammatory drug) not only prolongs colorectal cancer survival, but can also activate T cell...

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