Cell-free hemoglobin mediated oxidative stress is associated with acute kidney injury and renal replacement therapy in severe falciparum malaria: an observational study.

K, Plewes; HWF, Kingston; A, Ghose; RJ, Maude; MT, Herdman; SJ, Leopold; H, Ishioka; MMU, Hasan; MS, Haider; S, Alam; KA, Piera; P, Charunwatthana; K, Silamut; TW, Yeo; MA, Faiz; SJ, Lee; M, Mukaka; GDH, Turner; NM, Anstey; Roberts L 2nd, Jackson; NJ, White; NPJ, Day; MA, Hossain; AM, Dondorp

doi:10.1186/s12879-017-2373-1

Public

Cell-free hemoglobin mediated oxidative stress is associated with acute kidney injury and renal replacement therapy in severe falciparum malaria: an observational study.

Shared by NobleBlocks on Apr 27, 2017 • 12:00 AM UTC

Authors:

Plewes K

Kingston HWF

Ghose A

Abstract

<h4>Background</h4>Intravascular hemolysis is an intrinsic feature of severe malaria pathophysiology but the pathogenic role of cell-free hemoglobin-mediated oxidative stress in severe malaria associated acute kidney injury (AKI) is unknown.<h4>Methods</h4>As part of a prospective observational stud...

Subject

Oxidative stress

Pathophysiology

Acute Kidney Injury

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