Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism.

Y, Sapkota; V, Steinthorsdottir; AP, Morris; A, Fassbender; N, Rahmioglu; Vivo I, De; JE, Buring; F, Zhang; TL, Edwards; S, Jones; D, O; D, Peterse; KM, Rexrode; PM, Ridker; AJ, Schork; S, MacGregor; NG, Martin; CM, Becker; S, Adachi; K, Yoshihara; T, Enomoto; A, Takahashi; Y, Kamatani; K, Matsuda; M, Kubo; G, Thorleifsson; RT, Geirsson; U, Thorsteinsdottir; LM, Wallace; J, Yang; Edwards DR, Velez; M, Nyegaard; M, Nyegaard; SK, Low; KT, Zondervan; SA, Missmer; T, D'Hooghe; GW, Montgomery; DI, Chasman; K, Stefansson; JY, Tung; DR, Nyholt

doi:10.1038/ncomms15539

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Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism.

Shared by NobleBlocks on May 24, 2017 • 12:00 AM UTC

Authors:

Sapkota Y

Steinthorsdottir V

Morris AP

Abstract

Endometriosis is a heritable hormone-dependent gynecological disorder, associated with severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely unknown. Here we perform a meta-analysis of 11 genome-wide association case-control data sets, totalling 17,045 endometrio...

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