An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

Scott, R.; Scott, L.; Mägi, R.; Marullo, L.; Gaulton, K.; Kaakinen, M.; Pervjakova, N.; Pers, T.; D. Johnson, Andrew; Eicher, J.; Jackson, A.; Ferreira, T.; Lee, Yeji; Ma, Clement; Steinthorsdottir, V.; Thorleifsson, G.; Qi, L.; R. van Zuydam, Natalie; Mahajan, A.; Chen, Han; Almgren, P.; Voight, B.; Grallert, H.; Müller-Nurasyid, M.; Ried, J.; W. Rayner, N.; Robertson, N.; Karssen, L.; V. van Leeuwen, E.; M. Willems, Sara; Fuchsberger, C.; Kwan, P.; Teslovich, T.; Chanda, Pritam; Li, Man; Lu, Yingchang; Dina, C.; Thuillier, Dorothée; Yengo, L.; Jiang, Longda; Sparsø, T.; Kestler, H.; Chheda, H.; Eisele, L.; Gustafsson, S.; Frånberg, Mattias; Strawbridge, R.; Benediktsson, R.; Hreidarsson, Á.; Kong, A.; Sigurðsson, G.; Kerrison, N.; Luan, J.; Liang, L.; Meitinger, T.; Roden, M.; Thorand, B.; Esko, T.; Mihailov, E.; Fox, C.; Liu, Ching‐Ti; Rybin, Denis; Isomaa, B.; Lyssenko, V.; Tuomi, T.; Couper, D.; Pankow, J.; Grarup, N.; Have, C.; Jørgensen, M.; Jørgensen, T.; Linneberg, A.; C. Cornelis, Marilyn; V. van Dam, R.; Hunter, D.; Kraft, P.; Sun, Qi; Edkins, S.; Owen, K.; Perry, J.; Wood, A.; Zeggini, E.; Tajes-Fernandes, Juan; Abecasis, G.; Bonnycastle, L.; Chines, P.; Stringham, H.; Koistinen, H.; Kinnunen, L.; Sennblad, B.; W. Mühleisen, Thomas; Nöthen, M.; Pechlivanis, S.; Baldassarre, D.; Gertow, K.; Humphries, S.; Tremoli, E.; Klopp, N.; Meyer, Julia; Steinbach, G.; Wennauer, R.; Eriksson, J.; Mӓnnistö, S.; Peltonen, L.; Tikkanen, E.; Charpentier, G.; Eury, Elodie; Lobbens, S.; Gigante, B.; Leander, K.; Mcleod, O.; Bottinger, E.; Gottesman, O.; Ruderfer, D.; Blüher, M.; Kovacs, P.; Tonjes, Anke; Maruthur, N.; Scapoli, C.; Erbel, R.; Jöckel, K.; Moebus, S.; de Faire, U.; Hamsten, A.; Stumvoll, M.; Deloukas, P.; Donnelly, P.; Frayling, T.; Hattersley, A.; Ripatti, S.; Salomaa, V.; Pedersen, N.; Boehm, B.; Bergman, R.; Collins, F.; Mohlke, K.; Tuomilehto, J.; Hansen, T.; Pedersen, O.; Barroso, I.; Lannfelt, L.; Ingelsson, E.; Lind, L.; Lindgren, C.; Cauchi, S.; Froguel, P.; Loos, R.; Balkau, B.; Boeing, H.; Franks, P.; Barricarte Gurrea, A.; Palli, D.; T. van der Schouw, Y.; Altshuler, D.; Groop, L.; Langenberg, C.; Wareham, N.; Sijbrands, E.; V. van Duijn, C.; Florez, J.; Meigs, J.; Boerwinkle, E.; Gieger, C.; Strauch, K.; Metspalu, A.; Morris, A.; Palmer, C.; Hu, F.; Thorsteinsdóttir, U.; Stefánsson, K.; Dupuis, J.; P. Morris, Andrew; Boehnke, M.; McCarthy, M.; Prokopenko, I.

doi:10.2337/db16-1253

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An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.

Shared by NobleBlocks on May 31, 2017 • 12:00 AM UTC

Authors:

Scott RA

Scott LJ

Mägi R

Abstract

To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ancestry after imputation using the 1000 Genomes multiethnic reference panel. Pr...

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