Mismatch-repair deficiency predicts response of solid tumors to PD-1 blockade

T Le, Dung; T Le, Dung; N. Durham, Jennifer; N. Durham, Jennifer; N. Smith, Kellie; Wang, Hao; R. Bartlett, Bjarne; R. Bartlett, Bjarne; K. Aulakh, Laveet; K. Aulakh, Laveet; Lu, Steve; Lu, Steve; Kemberling, H.; Wilt, C.; S. Luber, Brandon; Wong, F.; Wong, F.; Azad, N.; Rucki, A.; Laheru, D.; Donehower, R.; Zaheer, A.; Fisher, G.; Crocenzi, T.; J. Lee, James; Greten, T.; Duffy, A.; Ciombor, K.; Eyring, A.; Lam, B.; Joe, A.; Kang, S.; Holdhoff, M.; V. Danilova, Ludmila; M. Cope, Leslie; Meyer, C.; Zhou, Shibin; Zhou, Shibin; Goldberg, R.; Armstrong, D.; M. Bever, Katherine; Fader, A.; Taube, J.; Housseau, F.; Spetzler, D.; Xiao, N.; Pardoll, D.; Papadopoulos, N.; Papadopoulos, N.; Kinzler, K.; Kinzler, K.; Eshleman, J.; Vogelstein, B.; Vogelstein, B.; A. Anders, Robert; A. Anders, Robert; Diaz, L.; Diaz, L.

doi:10.1126/science.aan6733

Public

Mismatch-repair deficiency predicts response of solid tumors to PD-1 blockade

Shared by NobleBlocks on Jun 8, 2017 • 12:00 AM UTC

Authors:

Dung T Le

Jennifer N. Durham

Abstract

Predicting responses to immunotherapy Colon cancers with loss-of-function mutations in the mismatch repair (MMR) pathway have favorable responses to PD-1 blockade immunotherapy. In a phase 2 clinical trial, Le et al. showed that treatment success is not just limited to colon cancer (see the Perspect...

Subject

Medicine

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