Effect of Antidepressant Switching vs Augmentation on Remission Among Patients With Major Depressive Disorder Unresponsive to Antidepressant Treatment: The VAST-D Randomized Clinical Trial

Mohamed, S.; R Johnson, Gary; Chen, Peijun; Hicks, P.; Davis, L.; Yoon, Jean; Gleason, T.; Vertrees, J.; Weingart, K.; R. Tal, Ilanit; Scrymgeour, A.; Lawrence, David; Planeta, B.; Thase, M.; D. Huang, Grant; Zisook, S.; Rao, Sanjai; D Pilkinton, Patricia; Wilcox, J.; Iranmanesh, A.; Sapra, M.; Jurjus, G.; P Michalets, James; Aslam, M.; Beresford, T.; Anderson, K.; S. Fernando, Ronald; Ramaswamy, S.; Kasckow, J.; Westermeyer, J.; Yoon, Gihyun; D’Souza, D.; Larson, Gunnar; Anderson, W.; J. Klatt, Mary; Fareed, Ayman; I Thompson, Shabnam; Carrera, C.; Williams, S.; Juergens, T.; Albers, L.; Nasdahl, C.; Villarreal, G.; Winston, Julian; A Nogues, Cristobal; R. Connolly, K.; Tapp, A.; Jones, Kari; Khatkhate, G.; Marri, S.; Suppes, T.; M LaMotte, Joseph; Hurley, R.; Mayeda, A.; Niculescu, A.; Fischer, B.; Loreck, D.; Rosenlicht, N.; Lieske, S.; Finkel, M.; Little, J.

doi:10.1001/jama.2017.8036

Public

Effect of Antidepressant Switching vs Augmentation on Remission Among Patients With Major Depressive Disorder Unresponsive to Antidepressant Treatment: The VAST-D Randomized Clinical Trial

Shared by NobleBlocks on Jul 11, 2017 • 12:00 AM UTC

Authors:

S. Mohamed

Gary R Johnson

Peijun Chen

Abstract

Importance Less than one-third of patients with major depressive disorder (MDD) achieve remission with their first antidepressant. Objective To determine the relative effectiveness and safety of 3 common alternate treatments for MDD. Design, Setting, and Participants From December 2012 to May 2015, ...

Subject

Medicine

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