Improving the thermal stability of cellobiohydrolase Cel7A from Hypocrea jecorina by directed evolution.

F, Goedegebuur; L, Dankmeyer; P, Gualfetti; S, Karkehabadi; H, Hansson; S, Jana; V, Huynh; BR, Kelemen; P, Kruithof; EA, Larenas; PJM, Teunissen; J, Ståhlberg; CM, Payne; C, Mitchinson; M, Sandgren

doi:10.1074/jbc.m117.803270

Public

Improving the thermal stability of cellobiohydrolase Cel7A from Hypocrea jecorina by directed evolution.

Shared by NobleBlocks on Aug 31, 2017 • 12:00 AM UTC

Authors:

Goedegebuur F

Dankmeyer L

Gualfetti P

Abstract

Secreted mixtures of Hypocrea jecorina cellulases are able to efficiently degrade cellulosic biomass to fermentable sugars at large, commercially relevant scales. H. jecorina Cel7A, cellobiohydrolase I, from glycoside hydrolase family 7, is the workhorse enzyme of the process. However,...

Subject

Cellulase

Aspergillus

Biotechnology

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