A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome

Khan, Akram; Benthin, Cody; Zeno, B.; Albertson, T.; Boyd, J.; Christie, J.; Hall, R.; Poirier, G.; Ronco, J.; Tidswell, M.; Hardes, K.; Powley, W.; Wright, T.; Siederer, S.; Fairman, D.; Lipson, D.; I. Bayliffe, Andrew; Lazaar, A.

doi:10.1186/s13054-017-1823-x

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A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome

Shared by NobleBlocks on Sep 7, 2017 • 12:00 AM UTC

Authors:

Akram Khan

Cody Benthin

B. Zeno

Abstract

BackgroundRenin-angiotensin system (RAS) signaling and angiotensin-converting enzyme 2 (ACE2) have been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS). We postulated that repleting ACE2 using GSK2586881, a recombinant form of human angiotensin-converting enzyme 2 (rhACE...

Subject

Medicine

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