Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

Barbeira, A.; P. Dickinson, Scott; Bonazzola, Rodrigo; Zheng, Jiamao; Wheeler, H.; M. Torres, Jason; Torstenson, E.; P. Shah, Kaanan; I. Garcia, Tzintzuni; Edwards, T.; Stahl, E.; Huckins, L.; Kristin G. Beryl B. Ellen T. Gad Kane Robert E. Ka Aguet Ardlie Cummings Gelfand Getz Hadley Handsake, François; Kristin G. Beryl B. Ellen T. Gad Kane Robert E. Ka Aguet Ardlie Cummings Gelfand Getz Hadley Handsake, François; Aguet, F.; Ardlie, K.; B. Cummings, Beryl; T. Gelfand, Ellen; Getz, G.; Hadley, Kane; Handsaker, R.; H. Huang, Katherine; Kashin, Seva; Karczewski, K.; Lek, M.; Li, Xiao; MacArthur, D.; L. Nedzel, Jared; T. Nguyen, D.; Noble, M.; Segrè, A.; A. Trowbridge, Casandra; Tukiainen, T.; S. Brunilda Ruth Omer Alexis Gireesh K. Andrew Chr Abell Balliu Barshir Basha Battle Bogu Brown Brown, Nathan; S. Abell, Nathan; Balliu, B.; Barshir, Ruth; Basha, Omer; Battle, A.; Bogu, G.; Brown, A.; D. Brown, Christopher; Castel, S.; S. Chen, Lin; Chiang, Colby; Conrad, D.; N. Damani, Farhan; R. Davis, Joe; Delaneau, O.; Dermitzakis, E.; Engelhardt, B.; Eskin, E.; G. Ferreira, Pedro; Frésard, L.; Gamazon, E.; Garrido-Martín, D.; D. H. Gewirtz, Ariel; Gliner, Genna; J. Gloudemans, Michael; Guigó, R.; Hall, I.; Han, Buhm; He, Yuan; Hormozdiari, F.; Howald, C.; Jo, Brian; Kang, E.; Kim, Yungil; Kim-Hellmuth, Sarah; Lappalainen, T.; Li, Gen; Li, Xin; Liu, Boxiang; Mangul, S.; McCarthy, M.; C. McDowell, Ian; Mohammadi, P.; Monlong, Jean; B. Montgomery, Stephen; Muñoz-Aguirre, Manuel; W. Ndungu, Anne; Nobel, A.; Oliva, Meritxell; Ongen, H.; Palowitch, John; Panousis, N.; K. Papasaikas, Panagiotis; Park, YoSon; Parsana, P.; J. Payne, Anthony; B. Peterson, Christine; Quan, J.; Reverter, F.; Sabatti, C.; Saha, A.; Sammeth, M.; J. Scott, Alexandra; Shabalin, A.; Sodaei, Reza; Stephens, M.; E. Stranger, Barbara; Strober, B.; Sul, J.; K. Tsang, Emily; Urbut, Sarah; van de Bunt, M.; Wang, Gao; Wen, Xiaoquan; A. Wright, Fred; Xi, H.; Yeger-Lotem, Esti; Zappala, Zachary; Zaugg, J.; Zhou, Yi-Hui; M. Daniel Joanne Lin S. Melina Kathryn Morgan Jenn Akey Bates Chan Chen Claussnitzer Demanelis Diegel, Joshua; Akey, J.; Bates, Daniel; Chan, Joanne; Claussnitzer, M.; Demanelis, Kathryn; Diegel, Morgan; Doherty, J.; Feinberg, A.; S. Fernando, Maria; Halow, J.; D. Hansen, Kasper; Haugen, E.; Hickey, P.; Hou, Lei; Jasmine, F.; Jian, Ruiqi; Jiang, Lihua; K. Johnson, Audra; Kaul, R.; Kellis, Manolis; Kibriya, M.; Lee, Kristen; B. Li, J.; Li, Qin; Li, Xiao; Lin, Jessica; Lin, Shin; Linder, Sandra; Linke, C.; Liu, Yaping; T. Maurano, Matthew; Molinie, B.; Nelson, Jemma; J. Neri, Fidencio; P. Park, Yongjin; Pierce, B.; J. Rinaldi, Nicola; Rizzardi, L.; Sandstrom, R.; D. Skol, Andrew; S. Smith, Kevin; P. Snyder, Michael; Stamatoyannopoulos, J.; Tang, Hua; Wang, Li; Wang, M.; Van Wittenberghe, Nicholas; Wu, Fan; Zhang, Rui; Nierras, C.; A. Latarsha J. Ping Helen M. Abhi Jimmie B. Branton Carithers Guan Moore Rao Vaught, Philip; Branton, P.; J. Carithers, Latarsha; Guan, P.; M. Moore, Helen; Rao, Abhi; Vaught, J.; E. Nicole C. Casey Jeffery P. Simona Gould Lockart Martin Struewing Volpi, Sarah; E. Gould, Sarah; C. Lockart, Nicole; Martin, Casey; Struewing, J.; Volpi, S.; M. Susan E. Addington Koester, Anjene; Addington, A.; E. Koester, Susan; Little, A.; E. Richard Marcus Christopher Mark Gene William F. Brigham Hasz Hunter Johns Johnson Kopen Leinweber, Lori; Brigham, L.; Hasz, R.; Hunter, Marcus; Johns, Christopher; Johnson, Mark; Kopen, G.; F. Leinweber, W.; Lonsdale, J.; McDonald, Alisa; Mestichelli, Bernadette; Myer, K.; Roe, Brian; Salvatore, Mike; Shad, Saboor; A. Thomas, Jeffrey; Walters, Gary; Washington, Michael; Wheeler, Joseph; Barbara A. Bryan M. Ellen Rachna Mark Michael T. Bridge Foster Gillard Karasik Kumar Miklos Moser, Jason; Bridge, J.; Foster, B.; M. Gillard, Bryan; Karasik, Ellen; Kumar, Rachna; Miklos, Mark; T. Moser, M.; D. Robert G. Daniel C. Dana R. Jewell Montroy Rohrer Valley, Scott; Jewell, S.; G. Montroy, Robert; Rohrer, D.; R. Valley, Dana; A. Deborah C. Davis Mash, David; A. Davis, David; C. Mash, Deborah; H. Anna M. David E. Nancy V. Jeffrey A. Negin Karn Undale Smith Tabor Roche McLean Vatanian Robinson, Anita; H. Undale, Anita; M. Smith, Anna; Tabor, D.; V. Roche, Nancy; McLean, J.; Vatanian, Negin; L. Robinson, Karna; Sobin, L.; Barcus, M.; M. Valentino, Kimberly; Qi, L.; Hunter, Steven; Hariharan, P.; Singh, Shilpi; S. Um, K.; Matose, Takunda; Tomaszewski, M.; K. Maghboeba Laura A. Heather M. Barker Mosavel Siminoff Traino, Laura; K. Barker, Laura; Mosavel, M.; Siminoff, L.; Traino, H.; Thomas Magali Dan Kieron Stephen J. Daniel R. Flicek Juettemann Ruffier Sheppard Taylor Trevanio, Paul; Flicek, Paul; Juettemann, Thomas; Ruffier, Magali; Sheppard, Daniel; Taylor, K.; Trevanion, S.; Zerbino, D.; Mary Maximilian W. James Christopher M. Benedict K Craft Goldman Haeussler Kent Lee Paten Rosenbloom, Brian; Craft, B.; Goldman, M.; Haeussler, M.; Kent, W.; M. Lee, Christopher; Paten, B.; Rosenbloom, K.; Vivian, John; Zhu, Jingchun; L. Nicolae, Dan; Cox, N.; Im, H.

doi:10.1038/s41467-018-03621-1

Public

Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

Shared by NobleBlocks on Mar 23, 2016 • 12:00 AM UTC

Authors:

A. Barbeira

Scott P. Dickinson

Rodrigo Bonazzola

Abstract

Scalable, integrative methods to understand mechanisms that link genetic variants with phenotypes are needed. Here we derive a mathematical expression to compute PrediXcan (a gene mapping approach) results using summary data (S-PrediXcan) and show its accuracy and general robustness to misspecified ...

Subject

Computer Science

Medicine

Biology

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!