Brain Oxygen Optimization in Severe Traumatic Brain Injury Phase-II: A Phase II Randomized Trial*

O. Okonkwo, David; Shutter, Lori; Moore, Carol; Temkin, Nancy; M. Puccio, Ava; J. Madden, Christopher; Andaluz, Norberto; M. Chesnut, Randall; Ross Bullock, M.; A. Grant, Gerald; McGregor, John; Weaver, Michael; Jallo, Jack; D. LeRoux, Peter; Moberg, Dick; Barber, Jason; Lazaridis, Christos; Diaz‐Arrastia, Ramon

doi:10.1097/ccm.0000000000002619

Public

Brain Oxygen Optimization in Severe Traumatic Brain Injury Phase-II: A Phase II Randomized Trial*

Published in Critical Care Medicine • Oct 15, 2017

Authors:

David O. Okonkwo

Lori Shutter

Carol Moore

Abstract

OBJECTIVES: A relationship between reduced brain tissue oxygenation and poor outcome following severe traumatic brain injury has been reported in observational studies. We designed a Phase II trial to assess whether a neurocritical care management protocol could improve brain tissue oxygenation leve...

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Open Access

Subject

Medicine

Intracranial pressure

Traumatic brain injury

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