Impaired K+ binding to glial glutamate transporter EAAT1 in migraine.

P, Kovermann; M, Hessel; D, Kortzak; JC, Jen; J, Koch; C, Fahlke; T, Freilinger

doi:10.1038/s41598-017-14176-4

Public

Impaired K+ binding to glial glutamate transporter EAAT1 in migraine.

Shared by NobleBlocks on Oct 24, 2017 • 12:00 AM UTC

Authors:

Kovermann P

Hessel M

Kortzak D

Abstract

SLC1A3 encodes the glial glutamate transporter hEAAT1, which removes glutamate from the synaptic cleft via stoichiometrically coupled Na+-K+-H+-glutamate transport. In a young man with migraine with aura including hemiplegia, we identified a novel SLC1A3 mutation tha...

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