Aquaporin-4-dependent glymphatic solute transport in the rodent brain.

H, Mestre; LM, Hablitz; AL, Xavier; W, Feng; W, Zou; T, Pu; H, Monai; G, Murlidharan; Rivera RM, Castellanos; MJ, Simon; MM, Pike; V, Plá; T, Du; BT, Kress; X, Wang; BA, Plog; AS, Thrane; I, Lundgaard; Y, Abe; M, Yasui; JH, Thomas; M, Xiao; H, Hirase; A, Asokan; JJ, Iliff; M, Nedergaard

doi:10.7554/elife.40070

Public

Aquaporin-4-dependent glymphatic solute transport in the rodent brain.

Shared by NobleBlocks on Dec 18, 2018 • 12:00 AM UTC

Authors:

Mestre H

Hablitz LM

Xavier AL

Abstract

The glymphatic system is a brain-wide clearance pathway; its impairment contributes to the accumulation of amyloid-β. Influx of cerebrospinal fluid (CSF) depends upon the expression and perivascular localization of the astroglial water channel aquaporin-4 (AQP4). Prompted by a recent failure to find...

Subject

Cerebrospinal fluid

Mouse

Neuroscience

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