Phospholipase A2 Receptor 1 Epitope Spreading at Baseline Predicts Reduced Likelihood of Remission of Membranous Nephropathy.

B, Seitz-Polski; H, Debiec; A, Rousseau; K, Dahan; C, Zaghrini; C, Payré; VLM, Esnault; G, Lambeau; P, Ronco

doi:10.1681/asn.2017070734

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Phospholipase A2 Receptor 1 Epitope Spreading at Baseline Predicts Reduced Likelihood of Remission of Membranous Nephropathy.

Shared by NobleBlocks on Nov 7, 2017 • 12:00 AM UTC

Authors:

Seitz-Polski B

Debiec H

Rousseau A

Abstract

The phospholipase A2 receptor (PLA2R1) is the major autoantigen in primary membranous nephropathy. Several PLA2R1 epitopes have been characterized, and a retrospective study identified PLA2R1 epitope spreading as a potential indicator of poor prognosis. Here, we analyzed the predictive value of anti...

Subject

Randomized controlled trials

immunosuppression

Membranous Nephropathy

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