YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias.

F, Llorens; K, Thüne; W, Tahir; E, Kanata; D, Diaz-Lucena; K, Xanthopoulos; E, Kovatsi; C, Pleschka; P, Garcia-Esparcia; M, Schmitz; D, Ozbay; S, Correia; Â, Correia; I, Milosevic; O, Andréoletti; N, Fernández-Borges; IM, Vorberg; M, Glatzel; T, Sklaviadis; JM, Torres; S, Krasemann; R, Sánchez-Valle; I, Ferrer; I, Zerr

doi:10.1186/s13024-017-0226-4

Public

YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias.

Shared by NobleBlocks on Nov 10, 2017 • 12:00 AM UTC

Authors:

Llorens F

Thüne K

Tahir W

Abstract

<h4>Background</h4>YKL-40 (also known as Chitinase 3-like 1) is a glycoprotein produced by inflammatory, cancer and stem cells. Its physiological role is not completely understood but YKL-40 is elevated in the brain and cerebrospinal fluid (CSF) in several neurological and neurodegenerative diseases...

Subject

Brain

Cerebrospinal fluid

neuroinflammation

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