Microglia express ABI3 in the brains of Alzheimer's disease and Nasu-Hakola disease.

Nasu-Hakola disease (NHD) is a rare autosomal recessive leukoencephalopathy caused by a loss-of-function mutation of either <i>TYROBP</i> (<i>DAP12</i>) or <i>TREM2</i> expressed in microglia. A rare variant of the <i>TREM2</i> gene encoding p.Arg47His causes a 3-fold increase in the risk for late-o... View More