Germinal Centers Determine the Prognostic Relevance of Tertiary Lymphoid Structures and Are Impaired by Corticosteroids in Lung Squamous Cell Carcinoma

Siliņa, Karīna; Soltermann, Alex; Movahedian Attar, Farkhondeh; Casanova, Ruben; M. Uckeley, Zina; Thut, Helen; Wandres, Muriel; Isajevs, Sergejs; Cheng, Phil; Curioni-Fontecedro, Alessandra; Foukas, Periklis; P. Levesque, Mitchell; Moch, Holger; Linē, Aija; van den Broek, Maries

doi:10.1158/0008-5472.can-17-1987

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Germinal Centers Determine the Prognostic Relevance of Tertiary Lymphoid Structures and Are Impaired by Corticosteroids in Lung Squamous Cell Carcinoma

Shared by NobleBlocks on Feb 28, 2018 • 12:00 AM UTC

Authors:

Karīna Siliņa

Alex Soltermann

Farkhondeh Movahedian Attar

Abstract

Abstract In solid tumors, the presence of lymph node–like structures called tertiary lymphoid structures (TLS) is associated with improved patient survival. However, little is known about how TLS develop in cancer, how their function affects survival, and whether they are affected by cancer therapy....

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