Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Turcot, Valérie; Lu, Yingchang; M. Highland, Heather; Schurmann, Claudia; E. Justice, Anne; S. Fine, Rebecca; P. Bradfield, Jonathan; Esko, Tõnu; Giri, Ayush; Graff, Mariaelisa; Guo, Xiuqing; E. Hendricks, Audrey; Karaderi, Tugce; Lempradl, Adelheid; E. Locke, Adam; Mahajan, Anubha; Marouli, Eirini; Sivapalaratnam, Suthesh; L. Young, Kristin; Alfred, Tamuno; F. Feitosa, Mary; G. D. Masca, Nicholas; K. Manning, Alisa; Medina-Gomez, Carolina; Mudgal, Poorva; C. Y. Ng, Maggie; P. Reiner, Alex; Vedantam, Sailaja; M. Willems, Sara; W. Winkler, Thomas; Abecasis, Gonçalo; K. Aben, Katja; S. Alam, Dewan; E. Alharthi, Sameer; Allison, Matthew; Amouyel, Philippe; W. Asselbergs, Folkert; L. Auer, Paul; Balkau, Beverley; E. Bang, Lia; Barroso, Inês; Bastarache, Lisa; Benn, Marianne; Bergmann, Sven; F. Bielak, Lawrence; Blüher, Matthias; Boehnke, Michael; Boeing, Heiner; Boerwinkle, Eric; A. Böger, Carsten; Bork-Jensen, Jette; L. Bots, Michiel; P. Bottinger, Erwin; W. Bowden, Donald; Brandslund, Ivan; Breen, Gerome; H. Brilliant, Murray; Broer, Linda; Brumat, Marco; A. Burt, Amber; S. Butterworth, Adam; T. Campbell, Peter; Cappellani, Stefania; J. Carey, David; Catamo, Eulalia; J. Caulfield, Mark; C. Chambers, John; I. Chasman, Daniel; I. Chen, Yii-Der; Chowdhury, Rajiv; Christensen, Cramer; Y. Chu, Audrey; Cocca, Massimiliano; S. Collins, Francis; P. Cook, James; Corley, Janie; Corominas Galbany, Jordi; J. Cox, Amanda; S. Crosslin, David; Cuellar-Partida, Gabriel; D’Eustacchio, Angela; Danesh, John; Davies, Gail; I. W. Bakker, Paul; C. H. Groot, Mark; Mutsert, Renée; J. Deary, Ian; Dedoussis, George; W. Demerath, Ellen; Heijer, Martin; I. Hollander, Anneke; M. Ruijter, Hester; G. Dennis, Joe; C. Denny, Josh; Di Angelantonio, Emanuele; Drenos, Fotios; Du, Mengmeng; Dubé, Marie-Pierre; M. Dunning, Alison; F. Easton, Douglas; L. Edwards, Todd; Ellinghaus, David; T. Ellinor, Patrick; Elliott, Paul; Evangelou, Evangelos; Farmaki, Aliki-Eleni; Sadaf Farooqi, I.; D. Faul, Jessica; Fauser, Sascha; Feng, Shuang; Ferrannini, Ele; Ferrieres, Jean; C. Florez, Jose; Ford, Ian; Fornage, Myriam; H. Franco, Oscar; Franke, Andre; W. Franks, Paul; Friedrich, Nele; Frikke-Schmidt, Ruth; E. Galesloot, Tessel; Gan, Wei; Gandin, Ilaria; Gasparini, Paolo; Gibson, Jane; Giedraitis, Vilmantas; P. Gjesing, Anette; Gordon-Larsen, Penny; Gorski, Mathias; Grabe, Hans-Jörgen; F. A. Grant, Struan; Grarup, Niels; L. Griffiths, Helen; L. Grove, Megan; Gudnason, Vilmundur; Gustafsson, Stefan; Haessler, Jeff; Hakonarson, Hakon; R. Hammerschlag, Anke; Hansen, Torben; Mullan Harris, Kathleen; B. Harris, Tamara; T. Hattersley, Andrew; T. Have, Christian; Hayward, Caroline; He, Liang; L. Heard-Costa, Nancy; C. Heath, Andrew; M. Heid, Iris; Helgeland, Øyvind; Hernesniemi, Jussi; W. Hewitt, Alex; L. Holmen, Oddgeir; Kees Hovingh, G.; M. M. Howson, Joanna; Hu, Yao; L. Huang, Paul; E. Huffman, Jennifer; Arfan Ikram, M.; Ingelsson, Erik; U. Jackson, Anne; Jansson, Jan-Håkan; P. Jarvik, Gail; B. Jensen, Gorm; Jia, Yucheng; Johansson, Stefan; E. Jørgensen, Marit; Jørgensen, Torben; Wouter Jukema, J.; Kahali, Bratati; S. Kahn, René; Kähönen, Mika; R. Kamstrup, Pia; Kanoni, Stavroula; Kaprio, Jaakko; Karaleftheri, Maria; L. R. Kardia, Sharon; Karpe, Fredrik; Kathiresan, Sekar; Kee, Frank; A. Kiemeney, Lambertus; Kim, Eric; Kitajima, Hidetoshi; Komulainen, Pirjo; S. Kooner, Jaspal; Kooperberg, Charles; Korhonen, Tellervo; Kovacs, Peter; Kuivaniemi, Helena; Kutalik, Zoltán; Kuulasmaa, Kari; Kuusisto, Johanna; Laakso, Markku; A. Lakka, Timo; Lamparter, David; M. Lange, Ethan; A. Lange, Leslie; Langenberg, Claudia; B. Larson, Eric; R. Lee, Nanette

doi:10.1038/s41588-017-0011-x

Public

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Shared by NobleBlocks on Dec 22, 2017 • 12:00 AM UTC

Authors:

Valérie Turcot

Yingchang Lu

Heather M. Highland

Research Assistant

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