The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates.

VG, Tsonkova; FW, Sand; XA, Wolf; LG, Grunnet; Ringgaard A, Kirstine; C, Ingvorsen; L, Winkel; M, Kalisz; K, Dalgaard; C, Bruun; JJ, Fels; C, Helgstrand; S, Hastrup; FK, Öberg; E, Vernet; MPB, Sandrini; AC, Shaw; C, Jessen; M, Grønborg; J, Hald; H, Willenbrock; D, Madsen; R, Wernersson; L, Hansson; JN, Jensen; A, Plesner; T, Alanentalo; MBK, Petersen; A, Grapin-Botton; C, Honoré; J, Ahnfelt-Rønne; J, Hecksher-Sørensen; P, Ravassard; OD, Madsen; C, Rescan; T, Frogne

doi:10.1016/j.molmet.2017.12.007

Public

The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates.

Shared by NobleBlocks on Dec 19, 2017 • 12:00 AM UTC

Authors:

Tsonkova VG

Sand FW

Wolf XA

Abstract

<h4>Objective</h4>To characterize the EndoC-βH1 cell line as a model for human beta cells and evaluate its beta cell functionality, focusing on insulin secretion, proliferation, apoptosis and ER stress, with the objective to assess its potential as a screening platform for identification of novel an...

Subject

Proliferation

Glucose Stimulated Insulin Secretion

Pseudoislets

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