Harmonized clinical trial methodologies for localized cutaneous leishmaniasis and potential for extensive network with capacities for clinical evaluation.

P, Olliaro; M, Grogl; M, Boni; EM, Carvalho; H, Chebli; M, Cisse; E, Diro; Cota G, Fernandes; AC, Erber; E, Gadisa; F, Handjani; A, Khamesipour; A, Llanos-Cuentas; Carvajal L, López; L, Grout; BE, Lmimouni; M, Mokni; MS, Nahzat; Salah A, Ben; Y, Ozbel; JM, Pascale; Molina N, Rizzo; J, Rode; G, Romero; JA, Ruiz-Postigo; Saravia N, Gore; J, Soto; S, Uzun; V, Mashayekhi; ID, Vélez; F, Vogt; O, Zerpa; B, Arana

doi:10.1371/journal.pntd.0006141

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Harmonized clinical trial methodologies for localized cutaneous leishmaniasis and potential for extensive network with capacities for clinical evaluation.

Published in PLoS neglected tropical diseases • Jan 12, 2018

Authors:

Olliaro P

Grogl M

Boni M

Abstract

<h4>Introduction</h4>Progress with the treatment of cutaneous leishmaniasis (CL) has been hampered by inconsistent methodologies used to assess treatment effects. A sizable number of trials conducted over the years has generated only weak evidence backing current treatment recommendations, as shown ...

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