Genetic and mechanistic diversity in pediatric hemophagocytic lymphohistiocytosis.

IK, Chinn; OS, Eckstein; EC, Peckham-Gregory; BR, Goldberg; LR, Forbes; SK, Nicholas; EM, Mace; TP, Vogel; HA, Abhyankar; MI, Diaz; HE, Heslop; RA, Krance; CA, Martinez; TC, Nguyen; DA, Bashir; JR, Goldman; A, Stray-Pedersen; LA, Pedroza; MC, Poli; JC, Aldave-Becerra; SA, McGhee; W, Al-Herz; A, Chamdin; ZH, Coban-Akdemir; SN, Jhangiani; DM, Muzny; TN, Cao; DN, Hong; RA, Gibbs; JR, Lupski; JS, Orange; KL, McClain; CE, Allen

doi:10.1182/blood-2017-11-814244

Public

Genetic and mechanistic diversity in pediatric hemophagocytic lymphohistiocytosis.

Shared by NobleBlocks on Apr 9, 2018 • 12:00 AM UTC

Authors:

Chinn IK

Eckstein OS

Peckham-Gregory EC

Abstract

The HLH-2004 criteria are used to diagnose hemophagocytic lymphohistiocytosis (HLH), yet concern exists for their misapplication, resulting in suboptimal treatment of some patients. We sought to define the genomic spectrum and associated outcomes of a diverse cohort of children who met the HLH-2004 ...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!