Conjugate Addition-Enantioselective Protonation of N-Aryl Glycines to α-Branched 2-Vinylazaarenes via Cooperative Photoredox and Asymmetric Catalysis.

Y, Yin; Y, Dai; H, Jia; J, Li; L, Bu; B, Qiao; X, Zhao; Z, Jiang

doi:10.1021/jacs.8b01575

Public

Conjugate Addition-Enantioselective Protonation of N-Aryl Glycines to α-Branched 2-Vinylazaarenes via Cooperative Photoredox and Asymmetric Catalysis.

Shared by NobleBlocks on Apr 19, 2018 • 12:00 AM UTC

Authors:

Yin Y

Dai Y

Jia H

Abstract

An enantioselective protonation strategy has been successfully applied to the synthesis of chiral α-tertiary azaarenes. With a dual catalytic system involving a chiral phosphoric acid and a dicyanopyrazine-derived chromophore (DPZ) photosensitizer that is mediated by visible light, a variety of α-br...

Discussions