CAR-T Cells Surface-Engineered with Drug-Encapsulated Nanoparticles Can Ameliorate Intratumoral T-cell Hypofunction.

N, Siriwon; YJ, Kim; E, Siegler; X, Chen; JA, Rohrs; Y, Liu; P, Wang

doi:10.1158/2326-6066.cir-17-0502

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CAR-T Cells Surface-Engineered with Drug-Encapsulated Nanoparticles Can Ameliorate Intratumoral T-cell Hypofunction.

Shared by NobleBlocks on May 2, 2018 • 12:00 AM UTC

Authors:

Siriwon N

Kim YJ

Siegler E

Abstract

One limiting factor of CAR T-cell therapy for treatment of solid cancers is the suppressive tumor microenvironment (TME), which inactivates the function of tumor-infiltrating lymphocytes (TIL) through the production of immunosuppressive molecules, such as adenosine. Adenosine inhibits the function o...

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