Human cytomegalovirus (HCMV)-specific T cell but not neutralizing or IgG binding antibody responses to glycoprotein complexes gB, gHgLgO, and pUL128L correlate with protection against high HCMV viral load reactivation in solid-organ transplant recipients.

D, Lilleri; P, Zelini; C, Fornara; F, Zavaglio; T, Rampino; L, Perez; E, Gabanti; G, Gerna

doi:10.1002/jmv.25225

Public

Human cytomegalovirus (HCMV)-specific T cell but not neutralizing or IgG binding antibody responses to glycoprotein complexes gB, gHgLgO, and pUL128L correlate with protection against high HCMV viral load reactivation in solid-organ transplant recipients.

Shared by NobleBlocks on Jul 10, 2018 • 12:00 AM UTC

Authors:

Lilleri D

Zelini P

Fornara C

Abstract

Immune correlates of protection against human cytomegalovirus (HCMV) infection are still debated. This study aimed to investigate which arm of the immune response plays a major role in protection against HCMV infection in kidney transplant recipients (n = 40) and heart transplant recipients (n = 12)...

Subject

Antibody response

Human cytomegalovirus (HCMV)

T-cell Response

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