STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion

Hsu, Jung-Mao; Xia, Weiya; Hsu, Yi-Hsin; Chan, Li-Chuan; Yu, Wen-Hsuan; Cha, Jong-Ho; Chen, Chun-Te; Liao, Hsin-Wei; Kuo, Chu-Wei; Khoo, Kay-Hooi; L. Hsu, Jennifer; Li, Chia-Wei; Lim, Seung-Oe; Chang, Shih-Shin; Chen, Yi-Chun; Ren, Guo-xin; Hung, Mien-Chie

doi:10.1038/s41467-018-04313-6

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STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion

Shared by NobleBlocks on May 15, 2018 • 12:00 AM UTC

Authors:

Jung-Mao Hsu

Weiya Xia

Yi-Hsin Hsu

Abstract

Abstract Enriched PD-L1 expression in cancer stem-like cells (CSCs) contributes to CSC immune evasion. However, the mechanisms underlying PD-L1 enrichment in CSCs remain unclear. Here, we demonstrate that epithelial–mesenchymal transition (EMT) enriches PD-L1 in CSCs by the EMT/β-catenin/STT3/PD-L1 ...

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