Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins.

AP, Hynes; GM, Rousseau; D, Agudelo; A, Goulet; B, Amigues; J, Loehr; DA, Romero; C, Fremaux; P, Horvath; Y, Doyon; C, Cambillau; S, Moineau

doi:10.1038/s41467-018-05092-w

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Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins.

Shared by NobleBlocks on Jul 25, 2018 • 12:00 AM UTC

Authors:

Hynes AP

Rousseau GM

Agudelo D

Abstract

CRISPR-Cas systems are bacterial anti-viral systems, and bacterial viruses (bacteriophages, phages) can carry anti-CRISPR (Acr) proteins to evade that immunity. Acrs can also fine-tune the activity of CRISPR-based genome-editing tools. While Acrs are prevalent in phages capable of lying dormant in a...

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