Cell-Specific Loss of SNAP25 from Cortical Projection Neurons Allows Normal Development but Causes Subsequent Neurodegeneration.

Hoerder-Suabedissen, A.; V Korrell, Kim; Hayashi, S.; Jeans, A.; M. O. Ramirez, Denise; Grant, Eleanor; Christian, H.; Kavalali, E.; C. Wilson, Michael; Molnár, Z.

doi:10.1093/cercor/bhy127

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Cell-Specific Loss of SNAP25 from Cortical Projection Neurons Allows Normal Development but Causes Subsequent Neurodegeneration.

Published in Cerebral cortex • May 30, 2018

Authors:

A. Hoerder-Suabedissen

Kim V Korrell

S. Hayashi

Abstract

Synaptosomal associated protein 25 kDa (SNAP25) is an essential component of the SNARE complex regulating synaptic vesicle fusion. SNAP25 deficiency has been implicated in a variety of cognitive disorders. We ablated SNAP25 from selected neuronal populations by generating a transgenic mouse (B6-Snap...

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Open Access

Subject

Biology

Medicine

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