Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

MF, Feitosa; AT, Kraja; DI, Chasman; YJ, Sung; TW, Winkler; I, Ntalla; X, Guo; N, Franceschini; CY, Cheng; X, Sim; D, Vojinovic; J, Marten; SK, Musani; C, Li; AR, Bentley; MR, Brown; K, Schwander; MA, Richard; R, Noordam; H, Aschard; TM, Bartz; LF, Bielak; R, Dorajoo; V, Fisher; FP, Hartwig; ARVR, Horimoto; KK, Lohman; AK, Manning; T, Rankinen; AV, Smith; SM, Tajuddin; MK, Wojczynski; M, Alver; M, Boissel; Q, Cai; A, Campbell; JF, Chai; X, Chen; J, Divers; C, Gao; A, Goel; Y, Hagemeijer; SE, Harris; M, He; FC, Hsu; AU, Jackson; M, Kähönen; A, Kasturiratne; P, Komulainen; B, Kühnel; F, Laguzzi; J, Luan; N, Matoba; IM, Nolte; S, Padmanabhan; M, Riaz; R, Rueedi; A, Robino; MA, Said; RA, Scott; T, Sofer; A, Stančáková; F, Takeuchi; BO, Tayo; der Most PJ, van; TV, Varga; V, Vitart; Y, Wang; EB, Ware; HR, Warren; S, Weiss; W, Wen; LR, Yanek; W, Zhang; JH, Zhao; S, Afaq; N, Amin; M, Amini; DE, Arking; T, Aung; E, Boerwinkle; I, Borecki; U, Broeckel; M, Brown; M, Brumat; GL, Burke; M, Canouil; A, Chakravarti; S, Charumathi; Chen YD, Ida; JM, Connell; A, Correa; las Fuentes L, de; Mutsert R, de; Silva HJ, de; X, Deng; J, Ding; Q, Duan; CB, Eaton; G, Ehret; RN, Eppinga; E, Evangelou; JD, Faul; SB, Felix; NG, Forouhi; T, Forrester; OH, Franco; Y, Friedlander; I, Gandin; H, Gao; M, Ghanbari; B, Gigante; CC, Gu; D, Gu; SP, Hagenaars; G, Hallmans; TB, Harris; J, He; S, Heikkinen; CK, Heng; M, Hirata; BV, Howard; MA, Ikram; U, John; T, Katsuya; CC, Khor; TO, Kilpeläinen; WP, Koh; JE, Krieger; SB, Kritchevsky; M, Kubo; J, Kuusisto; TA, Lakka; CD, Langefeld; C, Langenberg; LJ, Launer; B, Lehne; CE, Lewis; Y, Li; S, Lin; J, Liu; J, Liu; M, Loh; T, Louie; R, Mägi; CA, McKenzie; T, Meitinger; A, Metspalu; Y, Milaneschi; L, Milani; KL, Mohlke; Y, Momozawa; MA, Nalls; CP, Nelson; N, Sotoodehnia; JM, Norris; JR, O'Connell; ND, Palmer; T, Perls; NL, Pedersen; A, Peters; PA, Peyser; N, Poulter; LJ, Raffel; OT, Raitakari; K, Roll; LM, Rose; FR, Rosendaal; JI, Rotter; CO, Schmidt; PJ, Schreiner; N, Schupf; WR, Scott; PS, Sever; Y, Shi; S, Sidney; M, Sims; CM, Sitlani; JA, Smith; H, Snieder; JM, Starr; K, Strauch; HM, Stringham; NYQ, Tan; H, Tang; KD, Taylor; YY, Teo; YC, Tham; ST, Turner; AG, Uitterlinden; P, Vollenweider; M, Waldenberger; L, Wang; YX, Wang; WB, Wei; C, Williams; J, Yao; C, Yu; JM, Yuan

doi:10.1371/journal.pone.0198166

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Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

Shared by NobleBlocks on Jun 18, 2018 • 12:00 AM UTC

Authors:

Feitosa MF

Kraja AT

Chasman DI

Abstract

Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify a...

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