Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans.

H, Lin; H, Lyu; S, Zhou; J, Yu; NP, Keller; L, Chen; WB, Yin

doi:10.1039/c8ob01326h

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Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans.

Shared by NobleBlocks on Jul 1, 2018 • 12:00 AM UTC

Authors:

Lin H

Lyu H

Zhou S

Abstract

By disruption of LaeB, a global regulator recently characterized in Aspergillus nidulans, eight cryptic compounds in the mutant were identified, including seven polyketides and one NRPS-like product. Among the isolates, two phthalides and two dibenzo[1,4]dioxins are new compounds, revealing that the...

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