Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy

Logue, S.; P McGrath, Eoghan; Cleary, P.; Greene, S.; Mnich, K.; Almanza, Aitor; Chevet, É.; Dwyer, R.; Oommen, A.; Legembre, Patrick; Godey, F.; C. Madden, Emma; Leuzzi, Brian; Obacz, J.; Zeng, Qingping; Patterson, J.; Jäger, R.; Gorman, A.; Samali, Afshin

doi:10.1038/s41467-018-05763-8

Public

Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy

Shared by NobleBlocks on Aug 15, 2018 • 12:00 AM UTC

Authors:

S. Logue

Eoghan P McGrath

P. Cleary

Abstract

Triple-negative breast cancer (TNBC) lacks targeted therapies and has a worse prognosis than other breast cancer subtypes, underscoring an urgent need for new therapeutic targets and strategies. IRE1 is an endoplasmic reticulum (ER) stress sensor, whose activation is predominantly linked to the reso...

Subject

Medicine

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