4568 Background: Sitravatinib (MGCD516) is an oral, potent small molecule inhibitor of a closely related spectrum of receptor tyrosine kinases (RTKs) including the TAM family (AXL, MER), split RTKs (VEGFR2, PDGFR, KIT), RET and MET. Because of the importance of sitravatinib targets in the pathogenes...