Resveratrol ameliorates podocyte damage in diabetic mice via SIRT1/PGC-1α mediated attenuation of mitochondrial oxidative stress.

T, Zhang; Y, Chi; Y, Kang; H, Lu; H, Niu; W, Liu; Y, Li

doi:10.1002/jcp.27306

Public

Resveratrol ameliorates podocyte damage in diabetic mice via SIRT1/PGC-1α mediated attenuation of mitochondrial oxidative stress.

Shared by NobleBlocks on Sep 6, 2018 • 12:00 AM UTC

Authors:

Zhang T

Chi Y

Kang Y

Abstract

Excessive generation of mitochondrial reactive oxygen species (ROS) is considered to be initiating event in the development of diabetic nephropathy (DN). Mitochondrial biosynthesis mediated by coactivator PGC-1α and its downstream transcription factors NRF1 and TFAM may be a key target in maintainin...

Subject

Apoptosis

Oxidative stress

Diabetic nephropathy

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!