Dectin-1 Contributes to Myocardial Ischemia/Reperfusion Injury by Regulating Macrophage Polarization and Neutrophil Infiltration

Fan, Qin; Tao, Rong; Zhang, Hang; Xie, Hongyang; Lu, Lin; Wang, Ting; Su, Min; Hu, Jian; Zhang, Qi; Chen, Qiujing; Iwakura, Yoichiro; Shen, Weifeng; Zhang, Ruiyan; Yan, Xiaoxiang

doi:10.1161/circulationaha.118.036044

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Dectin-1 Contributes to Myocardial Ischemia/Reperfusion Injury by Regulating Macrophage Polarization and Neutrophil Infiltration

Shared by NobleBlocks on Jan 28, 2019 • 12:00 AM UTC

Authors:

Qin Fan

Rong Tao

Hang Zhang

Abstract

Background: Macrophage-associated immune response plays an important role in myocardial ischemia/reperfusion (IR) injury. Dectin-1, expressed mainly on activated myeloid cells, is crucial for the regulation of immune homeostasis as a pattern recognition receptor. However, its effects and roles durin...

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