Expression of AR-V7 and ARv<sup>567es</sup> in Circulating Tumor Cells Correlates with Outcomes to Taxane Therapy in Men with Metastatic Prostate Cancer Treated in TAXYNERGY.

ST, Tagawa; ES, Antonarakis; A, Gjyrezi; G, Galletti; S, Kim; D, Worroll; J, Stewart; A, Zaher; TP, Szatrowski; KV, Ballman; K, Kita; S, Tasaki; Y, Bai; L, Portella; BJ, Kirby; F, Saad; MA, Eisenberger; DM, Nanus; P, Giannakakou

doi:10.1158/1078-0432.ccr-18-0320

Public

Expression of AR-V7 and ARv<sup>567es</sup> in Circulating Tumor Cells Correlates with Outcomes to Taxane Therapy in Men with Metastatic Prostate Cancer Treated in TAXYNERGY.

Shared by NobleBlocks on Oct 9, 2018 • 12:00 AM UTC

Authors:

Tagawa ST

Antonarakis ES

Gjyrezi A

Abstract

<h4>Purpose</h4>Biomarkers aiding treatment optimization in metastatic castration-resistant prostate cancer (mCRPC) are scarce. The presence or absence of androgen receptor (AR) splice variants, AR-V7 and AR<sup>v567es</sup>, in mCRPC patient circulating tumor cells (CTC) may be associated with taxa...

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