Global expansion of &lt;i&gt;Mycobacterium tuberculosis&lt;/i&gt; lineage 4 shaped by colonial migration and local adaptation.

OB, Brynildsrud; CS, Pepperell; P, Suffys; L, Grandjean; J, Monteserin; N, Debech; J, Bohlin; K, Alfsnes; JO, Pettersson; I, Kirkeleite; F, Fandinho; Silva MA, da; J, Perdigao; I, Portugal; M, Viveiros; T, Clark; M, Caws; S, Dunstan; PVK, Thai; B, Lopez; V, Ritacco; A, Kitchen; TS, Brown; Soolingen D, van; MB, O'Neill; KE, Holt; EJ, Feil; B, Mathema; F, Balloux; V, Eldholm

doi:10.1126/sciadv.aat5869

Public

Global expansion of <i>Mycobacterium tuberculosis</i> lineage 4 shaped by colonial migration and local adaptation.

Shared by NobleBlocks on Oct 17, 2018 • 12:00 AM UTC

Authors:

Brynildsrud OB

Pepperell CS

Suffys P

Abstract

On the basis of population genomic and phylogeographic analyses of 1669 <i>Mycobacterium tuberculosis</i> lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colon...

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