Human CD96 Correlates to Natural Killer Cell Exhaustion and Predicts the Prognosis of Human Hepatocellular Carcinoma.

H, Sun; Q, Huang; M, Huang; H, Wen; R, Lin; M, Zheng; K, Qu; K, Li; H, Wei; W, Xiao; R, Sun; Z, Tian; C, Sun

doi:10.1002/hep.30347

Public

Human CD96 Correlates to Natural Killer Cell Exhaustion and Predicts the Prognosis of Human Hepatocellular Carcinoma.

Shared by NobleBlocks on Mar 5, 2019 • 12:00 AM UTC

Authors:

Sun H

Huang Q

Huang M

Abstract

Immune checkpoint blockade has become a promising therapeutic approach to reverse immune cell exhaustion. Coinhibitory CD96 and T-cell immunoglobulin and ITIM domain (TIGIT), together with costimulatory CD226, bind to common ligand CD155. The balancing between three receptors fine-tunes immune respo...

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