MitoTarget Modeling Using ANN-Classification Models Based on Fractal SEM Nano-Descriptors: Carbon Nanotubes as Mitochondrial F0F1-ATPase Inhibitors.

M, González-Durruthy; Nunes S, Manske; J, Ventura-Lima; MA, Gelesky; H, González-Díaz; JM, Monserrat; R, Concu; MNDS, Cordeiro

doi:10.1021/acs.jcim.8b00631

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MitoTarget Modeling Using ANN-Classification Models Based on Fractal SEM Nano-Descriptors: Carbon Nanotubes as Mitochondrial F0F1-ATPase Inhibitors.

Shared by NobleBlocks on Nov 27, 2018 • 12:00 AM UTC

Authors:

González-Durruthy M

Manske Nunes S

Ventura-Lima J

Abstract

Recently, it has been suggested that the mitochondrial oligomycin A-sensitive F0-ATPase subunit is an uncoupling channel linked to apoptotic cell death, and as such, the toxicological inhibition of mitochondrial F0-ATP hydrolase can be an interesting mitotoxicity-based therapy under pathological con...

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