Cap-specific terminal N 6-methylation of RNA by an RNA polymerase II-associated methyltransferase.

S, Akichika; S, Hirano; Y, Shichino; T, Suzuki; H, Nishimasu; R, Ishitani; A, Sugita; Y, Hirose; S, Iwasaki; O, Nureki; T, Suzuki

doi:10.1126/science.aav0080

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Cap-specific terminal N 6-methylation of RNA by an RNA polymerase II-associated methyltransferase.

Shared by NobleBlocks on Nov 22, 2018 • 12:00 AM UTC

Authors:

Akichika S

Hirano S

Shichino Y

Abstract

N 6-methyladenosine (m6A), a major modification of messenger RNAs (mRNAs), plays critical roles in RNA metabolism and function. In addition to the internal m6A, N 6, 2'-O-dimethyladenosine (m6Am) is present at the transcript...

Cap-specific terminal <i>N</i> <sup>6</sup>-methylation of RNA by an RNA polymerase II-associated methyltransferase.

Abstract

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