Molecular mechanisms of resistance to CDK4/6 inhibitors in breast cancer: A review

Pandey, Kamal; An, Hee‐Jung; Ki Kim, Seung; Ah Lee, Seung; Kim, Sewha; Min Lim, Sun; Min Kim, Gun; Sohn, Joohyuk; Wha Moon, Yong

doi:10.1002/ijc.32020

Public

Molecular mechanisms of resistance to CDK4/6 inhibitors in breast cancer: A review

Shared by NobleBlocks on Jan 7, 2019 • 12:00 AM UTC

Authors:

Kamal Pandey

Hee‐Jung An

Seung Ki Kim

Abstract

Deregulation of the cyclin D‐CDK4/6‐INK4‐RB pathway leading to uncontrolled cell proliferation, is frequently observed in breast cancer. Currently, three selective CDK4/6 inhibitors have been FDA approved: palbociclib, ribociclib and abemaciclib. Despite promising clinical outcomes, intrinsic or acq...

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