Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors

behalf of the Japan Pediatric Molecular Neuro-Oncology Group (JPMNG), on; Fukuoka, Kohei; Kanemura, Yonehiro; Shofuda, Tomoko; Fukushima, Shintaro; Yamashita, Satoshi; Narushima, Daichi; Kato, Mamoru; Honda‐Kitahara, Mai; Ichikawa, Hitoshi; Kohno, Takashi; Sasaki, Atsushi; Hirato, Junko; Hirose, Takanori; Komori, Takashi; Satomi, Kaishi; Yoshida, Akihiko; Yamasaki, Kai; Nakano, Yoshiko; Takada, Ai; Nakamura, Taishi; Takami, Hirokazu; Matsushita, Yuko; Suzuki, Tomonari; Nakamura, Hideo; Makino, Keishi; Sonoda, Yukihiko; Saito, Ryuta; Tominaga, Teiji; Matsusaka, Yasuhiro; Kobayashi, Keiichi; Nagane, Motoo; Furuta, Takuya; Nakada, Mitsutoshi; Narita, Yoshitaka; Hirose, Yuichi; Ohba, Shigeo; Wada, Akira; Shimizu, Katsuyoshi; Kurozumi, Kazuhiko; Date, Isao; Fukai, Junya; Miyairi, Yousuke; Kagawa, Naoki; Kawamura, Atsufumi; Yoshida, Makiko; Nishida, Namiko; Wataya, Takafumi; Yamaoka, Masayoshi; Tsuyuguchi, Naohiro; Uda, Takehiro; Takahashi, Mayu; Nakano, Yoshiteru; Akai, Takuya; Izumoto, Shuichi; Nonaka, Masahiro; Yoshifuji, Kazuhisa; Kodama, Yoshinori; Mano, Masayuki; Ozawa, Tatsuya; Ramaswamy, Vijay; D. Taylor, Michael; Ushijima, Toshikazu; Shibui, Soichiro; Yamasaki, Mami; Arai, Hajime; Sakamoto, Hiroaki; Nishikawa, Ryo; Ichimura, Koichi

doi:10.1186/s40478-018-0630-1

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Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors

Shared by NobleBlocks on Dec 1, 2018 • 12:00 AM UTC

Authors:

on behalf of the Japan Pediatric Molecular Neuro-Oncology Group (JPMNG)

Kohei Fukuoka

Yonehiro Kanemura

Abstract

Extensive molecular analyses of ependymal tumors have revealed that supratentorial and posterior fossa ependymomas have distinct molecular profiles and are likely to be different diseases. The presence of C11orf95-RELA fusion genes in a subset of supratentorial ependymomas (ST-EPN) indicated the exi...

Subject

Ependymoma

Biology

Methylation

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