TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models after Coronavirus Infection.

N, Iwata-Yoshikawa; T, Okamura; Y, Shimizu; H, Hasegawa; M, Takeda; N, Nagata

doi:10.1128/jvi.01815-18

Public

TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models after Coronavirus Infection.

Shared by NobleBlocks on Mar 5, 2019 • 12:00 AM UTC

Authors:

Iwata-Yoshikawa N

Okamura T

Shimizu Y

Abstract

Transmembrane serine protease TMPRSS2 activates the spike protein of highly pathogenic human coronaviruses such as severe acute respiratory syndrome-related coronavirus (SARS-CoV) and Middle East respiratory syndrome-related coronavirus (MERS-CoV). <i>In vitro</i>, activation induces virus-cell memb...

Subject

Animal model

SARS-Cov

Immunopathology

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!