The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells.

E, Perucha; R, Melchiotti; JA, Bibby; W, Wu; KS, Frederiksen; CA, Roberts; Z, Hall; G, LeFriec; KA, Robertson; P, Lavender; JG, Gerwien; LS, Taams; JL, Griffin; Rinaldis E, de; Baarsen LGM, van; C, Kemper; P, Ghazal; AP, Cope; AP, Cope

doi:10.1038/s41467-019-08332-9

Public

The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells.

Shared by NobleBlocks on Jan 30, 2019 • 12:00 AM UTC

Authors:

Perucha E

Melchiotti R

Bibby JA

Abstract

The mechanisms controlling CD4<sup>+</sup> T cell switching from an effector to an anti-inflammatory (IL-10<sup>+</sup>) phenotype play an important role in the persistence of chronic inflammatory diseases. Here, we identify the cholesterol biosynthesis pathway as a key regulator of this process. Pa...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!