Cyclin E1 Expression and Palbociclib Efficacy in Previously Treated Hormone Receptor-Positive Metastatic Breast Cancer.

NC, Turner; Y, Liu; Z, Zhu; S, Loi; M, Colleoni; S, Loibl; A, DeMichele; N, Harbeck; F, André; MA, Bayar; S, Michiels; Z, Zhang; C, Giorgetti; M, Arnedos; Bartlett C, Huang; M, Cristofanilli

doi:10.1200/jco.18.00925

Public

Cyclin E1 Expression and Palbociclib Efficacy in Previously Treated Hormone Receptor-Positive Metastatic Breast Cancer.

Shared by NobleBlocks on Feb 26, 2019 • 12:00 AM UTC

Authors:

Turner NC

Liu Y

Zhu Z

Abstract

<h4>Purpose</h4>A large-panel gene expression analysis was conducted to identify biomarkers associated with the effectiveness of adding palbociclib to fulvestrant.<h4>Methods</h4>The PALOMA-3 ( ClinicalTrials.gov identifier: NCT01942135) trial randomly assigned 521 endocrine-pretreated patients with...

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