Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice.

S, Jin; Y, Zong; Q, Gao; Z, Zhu; Y, Wang; P, Qin; C, Liang; D, Wang; JL, Qiu; F, Zhang; C, Gao

doi:10.1126/science.aaw7166

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Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice.

Shared by NobleBlocks on Feb 28, 2019 • 12:00 AM UTC

Authors:

Jin S

Zong Y

Gao Q

Abstract

Cytosine and adenine base editors (CBEs and ABEs) are promising new tools for achieving the precise genetic changes required for disease treatment and trait improvement. However, genome-wide and unbiased analyses of their off-target effects in vivo are still lacking. Our whole-genome sequencing anal...

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