MiR-499a-5p suppresses apoptosis of human nucleus pulposus cells and degradation of their extracellular matrix by targeting SOX4.

JC, Sun; B, Zheng; RX, Sun; YK, Meng; SM, Wang; HS, Yang; Y, Chen; JG, Shi; YF, Guo

doi:10.1016/j.biopha.2019.108652

Public

MiR-499a-5p suppresses apoptosis of human nucleus pulposus cells and degradation of their extracellular matrix by targeting SOX4.

Shared by NobleBlocks on Mar 8, 2019 • 12:00 AM UTC

Authors:

Sun JC

Zheng B

Sun RX

Abstract

Emerging evidence suggests that microRNAs (miRNAs, miRs) play important roles in the development of intervertebral disc degeneration (IVDD). Nonetheless, the expression level and biological function of miR-499a-5p in IVDD are still unclear. In this study, we found that miR-499a-5p was significantly ...

Subject

SOX4

Nucleus pulposus cell

Intervertebral Disc Degeneration

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