Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated IrIII Complex Conjugated to a Far-Red Emitting Coumarin.

V, Novohradsky; A, Rovira; C, Hally; A, Galindo; G, Vigueras; A, Gandioso; M, Svitelova; R, Bresolí-Obach; H, Kostrhunova; L, Markova; J, Kasparkova; S, Nonell; J, Ruiz; V, Brabec; V, Marchán

doi:10.1002/anie.201901268

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Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated IrIII Complex Conjugated to a Far-Red Emitting Coumarin.

Shared by NobleBlocks on Apr 4, 2019 • 12:00 AM UTC

Authors:

Novohradsky V

Rovira A

Hally C

Abstract

Although cyclometalated IrIII complexes have emerged as promising photosensitizers for photodynamic therapy, some key drawbacks still hamper clinical translation, such as operability in the phototherapeutic window and reactive oxygen species (ROS) production efficiency and selectivity. In...

Subject

Conjugation

Coumarin

Photodynamic therapy

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