Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression.

P, Goossens; J, Rodriguez-Vita; A, Etzerodt; M, Masse; O, Rastoin; V, Gouirand; T, Ulas; O, Papantonopoulou; Eck M, Van; N, Auphan-Anezin; M, Bebien; C, Verthuy; Manh TP, Vu; M, Turner; M, Dalod; JL, Schultze; T, Lawrence

doi:10.1016/j.cmet.2019.02.016

Public

Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression.

Shared by NobleBlocks on Mar 28, 2019 • 12:00 AM UTC

Authors:

Goossens P

Rodriguez-Vita J

Etzerodt A

Abstract

Macrophages possess intrinsic tumoricidal activity, yet tumor-associated macrophages (TAMs) rapidly adopt an alternative phenotype within the tumor microenvironment that is marked by tumor-promoting immunosuppressive and trophic functions. The mechanisms that promote such TAM polarization remain poo...

Subject

Cholesterol efflux

Ovarian cancer

lipid rafts

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