MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer.

YS, Weng; HY, Tseng; YA, Chen; PC, Shen; Haq AT, Al; LM, Chen; YC, Tung; HL, Hsu

doi:10.1186/s12943-019-0988-0

Public

MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer.

Shared by NobleBlocks on Mar 18, 2019 • 12:00 AM UTC

Authors:

Weng YS

Tseng HY

Chen YA

Abstract

<h4>Background</h4>Triple-negative breast cancer (TNBC) is a poor prognostic breast cancer with the highest mutations and limited therapeutic choices. Cytokine networking between cancer cells and the tumor microenvironment (TME) maintains the self-renewing subpopulation of breast cancer stem cells (...

Subject

Emt

M2 Macrophages

Cancer Stemness

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!