Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells.

KA, Kang; MJ, Piao; YJ, Hyun; AX, Zhen; SJ, Cho; MJ, Ahn; JM, Yi; JW, Hyun

doi:10.1038/s12276-019-0238-y

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Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells.

Shared by NobleBlocks on Apr 15, 2019 • 12:00 AM UTC

Authors:

Kang KA

Piao MJ

Hyun YJ

Abstract

Luteolin, a dietary flavone, modulates various signaling pathways involved in carcinogenesis. In this study, we investigated the molecular mechanism that underlies the apoptotic effects of luteolin mediated by DNA demethylation of the nuclear factor erythroid 2-related factor 2 (Nrf2) promoter and t...

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